Drug interactions
Clonazepam + Rifampin
Severity: Moderate
Clonazepam and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin induces hepatic enzymes and can reduce clonazepam concentrations, potentially weakening seizure or anxiety control. The effect develops over days to weeks and reverses after rifampin is stopped.
What this interaction means in plain words
Clonazepam and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin induction of CYP3A4 increases clonazepam metabolism.
What to do
Monitor clinical response and increase clonazepam dose if efficacy falls. Reduce the dose again if rifampin is discontinued to avoid excess sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Frequently asked questions
Can I take Clonazepam with Rifampin?
MediHelp rates the interaction as moderate. Clonazepam and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin induces hepatic enzymes and can reduce clonazepam concentrations, potentially weakening seizure or anxiety control. The effect develops over days to weeks and reverses after rifampin is stopped.
How serious is the interaction between Clonazepam and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and increase clonazepam dose if efficacy falls. Reduce the dose again if rifampin is discontinued to avoid excess sedation.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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