Drug interactions
Clonazepam + Scullcap
Severity: Minor
Clonazepam and Scullcap: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Skullcap has traditionally been used as a sedative herb and may add to the drowsiness caused by clonazepam. Evidence is limited and mostly theoretical.
What this interaction means in plain words
Clonazepam and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive GABAergic sedative activity of the herbal constituents; not well established.
What to do
Advise patients to report herbal use and to avoid driving if drowsy. Monitor sedation if the herb is used regularly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clonazepam and Scullcap, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Frequently asked questions
Can I take Clonazepam with Scullcap?
MediHelp rates the interaction as minor. Clonazepam and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Skullcap has traditionally been used as a sedative herb and may add to the drowsiness caused by clonazepam. Evidence is limited and mostly theoretical.
How serious is the interaction between Clonazepam and Scullcap?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to report herbal use and to avoid driving if drowsy. Monitor sedation if the herb is used regularly.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
