Drug interactions
Clonazepam + Triazolam
Severity: Moderate
Clonazepam and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking two benzodiazepines together adds to sedation, psychomotor impairment and the risk of respiratory depression. Falls, confusion and next-day impairment are more likely, especially in older adults.
What this interaction means in plain words
Clonazepam and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Both drugs enhance GABA-A receptor-mediated inhibition, producing additive CNS depression.
What to do
Avoid routine duplication of benzodiazepines and use the lowest effective doses for the shortest time. Monitor for excessive sedation and respiratory depression, particularly at bedtime dosing and in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Frequently asked questions
Can I take Clonazepam with Triazolam?
MediHelp rates the interaction as moderate. Clonazepam and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taking two benzodiazepines together adds to sedation, psychomotor impairment and the risk of respiratory depression. Falls, confusion and next-day impairment are more likely, especially in older adults.
How serious is the interaction between Clonazepam and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine duplication of benzodiazepines and use the lowest effective doses for the shortest time. Monitor for excessive sedation and respiratory depression, particularly at bedtime dosing and in older patients.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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