Drug interactions
Clonazepam + Trifluoperazine
Severity: Moderate
Clonazepam and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a benzodiazepine with a sedating phenothiazine antipsychotic increases drowsiness, dizziness and psychomotor impairment. Orthostatic hypotension and respiratory depression may also be additive.
What this interaction means in plain words
Clonazepam and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A potentiation by clonazepam and dopamine, histamine and adrenergic receptor blockade by trifluoperazine.
What to do
Monitor for sedation, hypotension and falls, and start with lower doses when combining. Counsel patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Frequently asked questions
Can I take Clonazepam with Trifluoperazine?
MediHelp rates the interaction as moderate. Clonazepam and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a benzodiazepine with a sedating phenothiazine antipsychotic increases drowsiness, dizziness and psychomotor impairment. Orthostatic hypotension and respiratory depression may also be additive.
How serious is the interaction between Clonazepam and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, hypotension and falls, and start with lower doses when combining. Counsel patients to avoid driving and alcohol.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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