Drug interactions
Clonazepam + Valerian
Severity: Moderate
Clonazepam and Valerian: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valerian has sedative properties that may add to the CNS depressant effect of clonazepam. This can increase drowsiness, slow reaction time and impair concentration.
What this interaction means in plain words
Clonazepam and Valerian can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, probably via enhancement of GABAergic activity by valerian constituents.
What to do
Counsel the patient to avoid valerian products while taking clonazepam, or monitor for excess sedation. Advise against driving or operating machinery if drowsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Frequently asked questions
Can I take Clonazepam with Valerian?
MediHelp rates the interaction as moderate. Clonazepam and Valerian can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valerian has sedative properties that may add to the CNS depressant effect of clonazepam. This can increase drowsiness, slow reaction time and impair concentration.
How serious is the interaction between Clonazepam and Valerian?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to avoid valerian products while taking clonazepam, or monitor for excess sedation. Advise against driving or operating machinery if drowsy.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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