Drug interactions
Clonidine + Diazepam
Severity: Moderate
Clonidine and Diazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, and clonidine can also lower blood pressure and heart rate. Together they can cause pronounced drowsiness, hypotension and dizziness.
What this interaction means in plain words
Clonidine and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonidine belongs to Cardiovascular; Diazepam belongs to Musculoskeletal.
Why it happens
Additive CNS depression from central alpha-2 agonism and GABA-A potentiation, with added hypotensive effects.
What to do
Monitor sedation, blood pressure and heart rate, and titrate doses gradually. Counsel patients on orthostatic precautions and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Frequently asked questions
Can I take Clonidine with Diazepam?
MediHelp rates the interaction as moderate. Clonidine and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS, and clonidine can also lower blood pressure and heart rate. Together they can cause pronounced drowsiness, hypotension and dizziness.
How serious is the interaction between Clonidine and Diazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and heart rate, and titrate doses gradually. Counsel patients on orthostatic precautions and driving.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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