Drug interactions
Clonidine + Doxylamine
Severity: Moderate
Clonidine and Doxylamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a sedating antihistamine that adds to the drowsiness caused by clonidine. Together they can impair alertness and psychomotor performance, particularly in older adults.
What this interaction means in plain words
Clonidine and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonidine belongs to Cardiovascular; Doxylamine belongs to Respiratory.
Why it happens
Additive CNS depressant effects.
What to do
Avoid combining where possible, or use the lowest doses and counsel on sedation and driving. Avoid alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Doxylamine
Frequently asked questions
Can I take Clonidine with Doxylamine?
MediHelp rates the interaction as moderate. Clonidine and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a sedating antihistamine that adds to the drowsiness caused by clonidine. Together they can impair alertness and psychomotor performance, particularly in older adults.
How serious is the interaction between Clonidine and Doxylamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, or use the lowest doses and counsel on sedation and driving. Avoid alcohol.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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