Drug interactions
Clonidine + Gliclazide
Severity: Moderate
Clonidine and Gliclazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clonidine can blunt the adrenergic warning signs of hypoglycemia such as tremor and palpitations, so low glucose may go unrecognized in patients taking gliclazide. It may also slightly affect glucose regulation.
What this interaction means in plain words
Clonidine and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonidine belongs to Cardiovascular; Gliclazide belongs to Endocrine.
Why it happens
Central alpha-2 agonism reduces sympathetic catecholamine response to hypoglycemia, masking warning symptoms.
What to do
Advise patients to monitor blood glucose regularly rather than relying on symptoms, and note that sweating may persist as a warning sign.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Frequently asked questions
Can I take Clonidine with Gliclazide?
MediHelp rates the interaction as moderate. Clonidine and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clonidine can blunt the adrenergic warning signs of hypoglycemia such as tremor and palpitations, so low glucose may go unrecognized in patients taking gliclazide. It may also slightly affect glucose regulation.
How serious is the interaction between Clonidine and Gliclazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to monitor blood glucose regularly rather than relying on symptoms, and note that sweating may persist as a warning sign.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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