Drug interactions
Clonidine + Glyburide-metformin
Severity: Minor
Clonidine and Glyburide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clonidine may blunt adrenergic warning symptoms of hypoglycemia such as tremor and palpitations, so low blood glucose may go unrecognized in patients taking glyburide. It does not usually change glucose levels itself.
What this interaction means in plain words
Clonidine and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clonidine belongs to Cardiovascular; Glyburide-metformin belongs to Endocrine.
Why it happens
Central alpha-2 agonism reduces sympathetic and catecholamine responses to hypoglycemia.
What to do
Advise patients to monitor blood glucose regularly and not to rely on adrenergic symptoms to detect hypoglycemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Frequently asked questions
Can I take Clonidine with Glyburide-metformin?
MediHelp rates the interaction as minor. Clonidine and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clonidine may blunt adrenergic warning symptoms of hypoglycemia such as tremor and palpitations, so low blood glucose may go unrecognized in patients taking glyburide. It does not usually change glucose levels itself.
How serious is the interaction between Clonidine and Glyburide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to monitor blood glucose regularly and not to rely on adrenergic symptoms to detect hypoglycemia.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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