Drug interactions
Clonidine + Glycerol phenylbutyrate
Severity: Minor
Clonidine and Glycerol phenylbutyrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glycerol phenylbutyrate is a weak CYP3A4 inducer, but CYP3A4 plays only a limited role in clonidine elimination. A clinically relevant loss of blood pressure control is unlikely.
What this interaction means in plain words
Clonidine and Glycerol phenylbutyrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clonidine belongs to Cardiovascular; Glycerol phenylbutyrate belongs to Miscellaneous.
Why it happens
Weak CYP3A4 induction might slightly increase clonidine metabolism.
What to do
No routine adjustment is needed. Check blood pressure if control appears to worsen after starting glycerol phenylbutyrate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Glycerol phenylbutyrate
- Dexamethasone + Glycerol phenylbutyrate Major
- Glycerol phenylbutyrate + Valproic acid Major
- Cyclosporin + Glycerol phenylbutyrate Moderate
- Dexamethasone-neomycin-polymyxin + Glycerol phenylbutyrate Moderate
- Dexamethasone-tobramycin + Glycerol phenylbutyrate Moderate
- Fludrocortisone + Glycerol phenylbutyrate Moderate
Frequently asked questions
Can I take Clonidine with Glycerol phenylbutyrate?
MediHelp rates the interaction as minor. Clonidine and Glycerol phenylbutyrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glycerol phenylbutyrate is a weak CYP3A4 inducer, but CYP3A4 plays only a limited role in clonidine elimination. A clinically relevant loss of blood pressure control is unlikely.
How serious is the interaction between Clonidine and Glycerol phenylbutyrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Check blood pressure if control appears to worsen after starting glycerol phenylbutyrate.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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