Drug interactions
Clonidine + Insulin glargine-lixisenatide
Severity: Minor
Clonidine and Insulin glargine-lixisenatide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clonidine may blunt the adrenergic warning symptoms of hypoglycemia such as tremor and palpitations. It may also slightly alter glucose control, so low blood glucose could go unrecognized.
What this interaction means in plain words
Clonidine and Insulin glargine-lixisenatide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clonidine belongs to Cardiovascular; Insulin glargine-lixisenatide belongs to Endocrine.
Why it happens
Central alpha-2 agonism reduces sympathetic and catecholamine responses to hypoglycemia.
What to do
Advise patients to monitor blood glucose more frequently and not to rely on adrenergic symptoms; sweating is usually preserved.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Frequently asked questions
Can I take Clonidine with Insulin glargine-lixisenatide?
MediHelp rates the interaction as minor. Clonidine and Insulin glargine-lixisenatide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clonidine may blunt the adrenergic warning symptoms of hypoglycemia such as tremor and palpitations. It may also slightly alter glucose control, so low blood glucose could go unrecognized.
How serious is the interaction between Clonidine and Insulin glargine-lixisenatide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to monitor blood glucose more frequently and not to rely on adrenergic symptoms; sweating is usually preserved.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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