Drug interactions
Clonidine + Oxazepam
Severity: Moderate
Clonidine and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clonidine and oxazepam both cause sedation, so combined use can increase drowsiness, psychomotor impairment and dizziness. Hypotension may also be additive, with higher risk in older adults.
What this interaction means in plain words
Clonidine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonidine belongs to Cardiovascular; Oxazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression via central alpha-2 agonism and GABA-A potentiation.
What to do
Use the lowest effective doses and monitor sedation and blood pressure. Advise patients to avoid driving and alcohol until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Frequently asked questions
Can I take Clonidine with Oxazepam?
MediHelp rates the interaction as moderate. Clonidine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clonidine and oxazepam both cause sedation, so combined use can increase drowsiness, psychomotor impairment and dizziness. Hypotension may also be additive, with higher risk in older adults.
How serious is the interaction between Clonidine and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and blood pressure. Advise patients to avoid driving and alcohol until the response is known.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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