Drug interactions
Clonidine + Tadalafil
Severity: Minor
Clonidine and Tadalafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil may add to the blood pressure lowering effect of clonidine, potentially causing dizziness or hypotension. Clinically significant effects are uncommon at usual doses.
What this interaction means in plain words
Clonidine and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clonidine belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Additive pharmacodynamic blood pressure lowering from vasodilation and central sympatholytic action.
What to do
Monitor blood pressure after starting tadalafil and counsel on dizziness; avoid abrupt clonidine withdrawal.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Frequently asked questions
Can I take Clonidine with Tadalafil?
MediHelp rates the interaction as minor. Clonidine and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tadalafil may add to the blood pressure lowering effect of clonidine, potentially causing dizziness or hypotension. Clinically significant effects are uncommon at usual doses.
How serious is the interaction between Clonidine and Tadalafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting tadalafil and counsel on dizziness; avoid abrupt clonidine withdrawal.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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