Drug interactions
Clopidogrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Contraindicated
Clopidogrel and Ombitasvir / paritaprevir / ritonavir and dasabuvir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clopidogrel's acyl glucuronide metabolite is a strong CYP2C8 inhibitor, which markedly raises dasabuvir exposure. Higher dasabuvir levels raise concern for QT prolongation. The regimen labeling contraindicates strong CYP2C8 inhibitors.
What this interaction means in plain words
Clopidogrel and Ombitasvir / paritaprevir / ritonavir and dasabuvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Inhibition of CYP2C8 by the clopidogrel glucuronide metabolite reduces dasabuvir metabolism.
What to do
Avoid the combination and use an alternative antiplatelet such as prasugrel, if suitable. Seek alternative HCV therapy if clopidogrel is essential.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as contraindicated. Clopidogrel and Ombitasvir / paritaprevir / ritonavir and dasabuvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clopidogrel's acyl glucuronide metabolite is a strong CYP2C8 inhibitor, which markedly raises dasabuvir exposure. Higher dasabuvir levels raise concern for QT prolongation. The regimen labeling contraindicates strong CYP2C8 inhibitors.
How serious is the interaction between Clopidogrel and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antiplatelet such as prasugrel, if suitable. Seek alternative HCV therapy if clopidogrel is essential.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Abrocitinib, Acetylsalicylic acid, Apixaban. The full list is on the Clopidogrel page.
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