Drug reference
clopidogrel
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Anti Platelets)
Mechanism of action
Inhibitor of adenosine diphosphate (ADP)-induced pathway for platelet aggregation
Common side effects
- Upper respiratory tract infection
- Arthralgia
- Headache
- Pain
- Chest pain
- Flulike syndrome
Boxed warnings
- Clopidogrel's antiplatelet activity is dependent on conversion to an active metabolite by the cytochrome P450 (CYP) system, principally CYP2C19 Tests are available to identify patients who are CYP2C19 poor metabolizers Consider use of another platelet P2Y12 inhibitor in patients identified as CYP2C19 poor metabolizers
- Clopidogrel's antiplatelet activity is dependent on conversion to an active metabolite by the cytochrome P450 (CYP) system, principally CYP2C19 Tests are available to identify patients who are CYP2C19 poor metabolizers Consider use of another platelet P2Y12 inhibitor in patients identified as CYP2C19 poor metabolizers
Contraindications
- Active pathologic bleeding (eg, peptic ulcer, intracranial hemorrhage)
Known interactions (15)
- aspirin + clopidogrel Major
- clopidogrel + dalteparin Major
- clopidogrel + esomeprazole Major
- clopidogrel + fondaparinux Major
- clopidogrel + heparin Major
- clopidogrel + omeprazole Major
- clopidogrel + warfarin Major
- Amlodipine/Valsartan/Hydrochlorothiazide + clopidogrel Moderate
- argatroban + clopidogrel Moderate
- clopidogrel + ginkgo biloba Moderate
- clopidogrel + omega-3 fatty acids Moderate
- clopidogrel + Omega-3-acid ethyl esters Moderate
- clopidogrel + pantoprazole Moderate
- clopidogrel + prednisone Moderate
- clopidogrel + rosuvastatin Moderate
Related conditions
Frequently asked questions
What drug class is clopidogrel?
clopidogrel belongs to: Cardiovascular.
How does clopidogrel work?
Inhibitor of adenosine diphosphate (ADP)-induced pathway for platelet aggregation
What are the common side effects of clopidogrel?
Upper respiratory tract infection, Arthralgia, Headache, Pain, Chest pain, Flulike syndrome
Which drugs interact with clopidogrel?
aspirin, dalteparin, esomeprazole, fondaparinux, heparin, omeprazole, warfarin, Amlodipine/Valsartan/Hydrochlorothiazide, argatroban, ginkgo biloba, omega-3 fatty acids, Omega-3-acid ethyl esters, pantoprazole, prednisone, rosuvastatin
Full monographs, dosing and an interaction checker in the MediHelp app
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