Drug interactions
Clozapine + Cortisone
Severity: Minor
Clozapine and Cortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids are weak CYP3A4 inducers and could slightly lower clozapine exposure, but a clinically important effect is not well documented. Corticosteroids can also worsen glucose control and mood, which matters in clozapine-treated patients.
What this interaction means in plain words
Clozapine and Cortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 induction by cortisone, with minor contribution to clozapine clearance.
What to do
No dose change is usually needed; monitor psychiatric status and blood glucose during prolonged corticosteroid therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Cortisone?
MediHelp rates the interaction as minor. Clozapine and Cortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids are weak CYP3A4 inducers and could slightly lower clozapine exposure, but a clinically important effect is not well documented. Corticosteroids can also worsen glucose control and mood, which matters in clozapine-treated patients.
How serious is the interaction between Clozapine and Cortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor psychiatric status and blood glucose during prolonged corticosteroid therapy.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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