Drug interactions
Clozapine + Deferasirox
Severity: Moderate
Clozapine and Deferasirox: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can inhibit CYP1A2, the main enzyme clearing clozapine, so clozapine levels may rise. Higher exposure can bring sedation, hypotension, seizures and other dose-related adverse effects.
What this interaction means in plain words
Clozapine and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Deferasirox belongs to Miscellaneous.
Why it happens
Inhibition of CYP1A2-mediated clozapine metabolism by deferasirox.
What to do
Watch for signs of clozapine toxicity after deferasirox is started and consider checking clozapine plasma levels. Reduce the clozapine dose if levels or adverse effects increase.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clozapine and Deferasirox, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Clozapine with Deferasirox?
MediHelp rates the interaction as moderate. Clozapine and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox can inhibit CYP1A2, the main enzyme clearing clozapine, so clozapine levels may rise. Higher exposure can bring sedation, hypotension, seizures and other dose-related adverse effects.
How serious is the interaction between Clozapine and Deferasirox?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for signs of clozapine toxicity after deferasirox is started and consider checking clozapine plasma levels. Reduce the clozapine dose if levels or adverse effects increase.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
