Drug interactions
Clozapine + Dexfenfluramine
Severity: Moderate
Clozapine and Dexfenfluramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexfenfluramine is a serotonin-releasing agent that was withdrawn from the market, and combining it with clozapine carries a theoretical risk of serotonergic toxicity. Their effects on sedation oppose each other unpredictably.
What this interaction means in plain words
Clozapine and Dexfenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing CNS effects and possible additive serotonergic activity; not well characterized.
What to do
Avoid if the drug is encountered, and monitor for agitation, tremor, hyperthermia and autonomic instability if used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Dexfenfluramine?
MediHelp rates the interaction as moderate. Clozapine and Dexfenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexfenfluramine is a serotonin-releasing agent that was withdrawn from the market, and combining it with clozapine carries a theoretical risk of serotonergic toxicity. Their effects on sedation oppose each other unpredictably.
How serious is the interaction between Clozapine and Dexfenfluramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if the drug is encountered, and monitor for agitation, tremor, hyperthermia and autonomic instability if used.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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