Drug interactions
Clozapine + Dextroamphetamine
Severity: Moderate
Clozapine and Dextroamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextroamphetamine may counter the sedation of clozapine, but stimulants can worsen psychosis, and both drugs can cause tachycardia. Clozapine's dopamine and adrenergic blockade may also blunt stimulant effects.
What this interaction means in plain words
Clozapine and Dextroamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Dextroamphetamine belongs to Central Nervous System.
Why it happens
Pharmacodynamic opposition at dopaminergic and adrenergic receptors, with additive effects on heart rate.
What to do
Monitor psychotic symptoms, heart rate and blood pressure when combining. Use the lowest effective stimulant dose and reassess if psychosis worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Dextroamphetamine?
MediHelp rates the interaction as moderate. Clozapine and Dextroamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dextroamphetamine may counter the sedation of clozapine, but stimulants can worsen psychosis, and both drugs can cause tachycardia. Clozapine's dopamine and adrenergic blockade may also blunt stimulant effects.
How serious is the interaction between Clozapine and Dextroamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychotic symptoms, heart rate and blood pressure when combining. Use the lowest effective stimulant dose and reassess if psychosis worsens.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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