Drug interactions
Clozapine + DHEA herbal
Severity: Minor
Clozapine and DHEA herbal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
DHEA may affect CYP3A4 activity, but the direction and size of any effect on clozapine are not established. DHEA has also been reported to cause psychiatric effects such as mania or agitation, which may complicate psychosis management.
What this interaction means in plain words
Clozapine and DHEA herbal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible modulation of CYP3A4 by DHEA; not clearly established.
What to do
Avoid unsupervised DHEA supplements in patients with psychosis, and monitor mental state and clozapine response if used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with DHEA herbal?
MediHelp rates the interaction as minor. Clozapine and DHEA herbal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. DHEA may affect CYP3A4 activity, but the direction and size of any effect on clozapine are not established. DHEA has also been reported to cause psychiatric effects such as mania or agitation, which may complicate psychosis management.
How serious is the interaction between Clozapine and DHEA herbal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unsupervised DHEA supplements in patients with psychosis, and monitor mental state and clozapine response if used.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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