Drug interactions
Clozapine + Diethylpropion
Severity: Moderate
Clozapine and Diethylpropion: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diethylpropion is a sympathomimetic stimulant that may offset clozapine sedation but can worsen agitation or psychosis and add to tachycardia and blood pressure effects. The net effect is unpredictable.
What this interaction means in plain words
Clozapine and Diethylpropion can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing CNS effects and additive sympathomimetic cardiovascular effects; no established pharmacokinetic mechanism.
What to do
Monitor heart rate, blood pressure and psychiatric symptoms, and stop the anorectic if agitation or psychosis worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Diethylpropion?
MediHelp rates the interaction as moderate. Clozapine and Diethylpropion can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diethylpropion is a sympathomimetic stimulant that may offset clozapine sedation but can worsen agitation or psychosis and add to tachycardia and blood pressure effects. The net effect is unpredictable.
How serious is the interaction between Clozapine and Diethylpropion?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and psychiatric symptoms, and stop the anorectic if agitation or psychosis worsens.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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