Drug interactions
Clozapine + Difenoxin
Severity: Moderate
Clozapine and Difenoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difenoxin is an opioid antidiarrheal metabolite that can cause drowsiness, and with clozapine sedation may be additive. Both drugs slow gut motility, so constipation or ileus risk may also rise.
What this interaction means in plain words
Clozapine and Difenoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Difenoxin belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression and reduced gastrointestinal motility.
What to do
Monitor sedation and bowel function, and limit antidiarrheal use to short courses. Seek review if abdominal distension or constipation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Difenoxin
Frequently asked questions
Can I take Clozapine with Difenoxin?
MediHelp rates the interaction as moderate. Clozapine and Difenoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difenoxin is an opioid antidiarrheal metabolite that can cause drowsiness, and with clozapine sedation may be additive. Both drugs slow gut motility, so constipation or ileus risk may also rise.
How serious is the interaction between Clozapine and Difenoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and bowel function, and limit antidiarrheal use to short courses. Seek review if abdominal distension or constipation develops.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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