Drug interactions
Clozapine + Dipipanone
Severity: Major
Clozapine and Dipipanone: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine and the opioid dipipanone each depress the central nervous system, so together they can cause marked drowsiness, impaired psychomotor function and respiratory depression. Clozapine can also cause orthostatic hypotension and circulatory collapse, which opioids may worsen.
What this interaction means in plain words
Clozapine and Dipipanone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive central nervous system and respiratory depression, with additive hypotensive effects.
What to do
Start dipipanone at a reduced dose and titrate slowly while monitoring sedation, respiratory rate and blood pressure. Counsel the patient to avoid driving and other hazardous tasks.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Dipipanone?
MediHelp rates the interaction as major. Clozapine and Dipipanone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clozapine and the opioid dipipanone each depress the central nervous system, so together they can cause marked drowsiness, impaired psychomotor function and respiratory depression. Clozapine can also cause orthostatic hypotension and circulatory collapse, which opioids may worsen.
How serious is the interaction between Clozapine and Dipipanone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start dipipanone at a reduced dose and titrate slowly while monitoring sedation, respiratory rate and blood pressure. Counsel the patient to avoid driving and other hazardous tasks.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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