Drug interactions
Clozapine + Ergoloid mesylates
Severity: Moderate
Clozapine and Ergoloid mesylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergoloid mesylates have mixed dopaminergic and serotonergic activity, which may interact with the strong dopamine and serotonin receptor antagonism of clozapine. The interaction is poorly characterized, but theoretical concerns include altered antipsychotic effect, neuroleptic malignant syndrome or serotonin toxicity. Additive hypotension is also possible.
What this interaction means in plain words
Clozapine and Ergoloid mesylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing dopaminergic and serotonergic receptor activity; the exact mechanism is not firmly established.
What to do
Monitor for mental status changes, fever, rigidity, autonomic instability and blood pressure changes when combining. Stop ergoloid if signs of neuroleptic malignant syndrome or serotonin toxicity appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Ergoloid mesylates?
MediHelp rates the interaction as moderate. Clozapine and Ergoloid mesylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ergoloid mesylates have mixed dopaminergic and serotonergic activity, which may interact with the strong dopamine and serotonin receptor antagonism of clozapine. The interaction is poorly characterized, but theoretical concerns include altered antipsychotic effect, neuroleptic malignant syndrome or serotonin toxicity. Additive hypotension is also possible.
How serious is the interaction between Clozapine and Ergoloid mesylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status changes, fever, rigidity, autonomic instability and blood pressure changes when combining. Stop ergoloid if signs of neuroleptic malignant syndrome or serotonin toxicity appear.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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