Drug interactions
Clozapine + Glibenclamide
Severity: Moderate
Clozapine and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine often causes weight gain, insulin resistance and hyperglycemia, which can reduce the effectiveness of glyburide. Glycemic control may deteriorate.
What this interaction means in plain words
Clozapine and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Glibenclamide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism, as clozapine induces insulin resistance and impairs glucose regulation.
What to do
Monitor blood glucose and HbA1c regularly, particularly after starting or changing clozapine. Adjust the glyburide dose or add other agents as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Clozapine with Glibenclamide?
MediHelp rates the interaction as moderate. Clozapine and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine often causes weight gain, insulin resistance and hyperglycemia, which can reduce the effectiveness of glyburide. Glycemic control may deteriorate.
How serious is the interaction between Clozapine and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c regularly, particularly after starting or changing clozapine. Adjust the glyburide dose or add other agents as needed.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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