Drug interactions
Clozapine + Glimepiride-pioglitazone
Severity: Moderate
Clozapine and Glimepiride-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine can cause weight gain, insulin resistance and hyperglycemia, which can work against the glucose-lowering effect of the sulfonylurea and thiazolidinedione. Glycemic control may deteriorate, and diabetes can be newly unmasked or worsen in treated patients.
What this interaction means in plain words
Clozapine and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Glimepiride-pioglitazone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: clozapine induces metabolic disturbances including insulin resistance and impaired insulin secretion, opposing antidiabetic drug effects.
What to do
Monitor fasting glucose and HbA1c at baseline and regularly during clozapine therapy, and increase the antidiabetic regimen if control worsens. Also monitor weight and lipids.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Glimepiride-pioglitazone?
MediHelp rates the interaction as moderate. Clozapine and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine can cause weight gain, insulin resistance and hyperglycemia, which can work against the glucose-lowering effect of the sulfonylurea and thiazolidinedione. Glycemic control may deteriorate, and diabetes can be newly unmasked or worsen in treated patients.
How serious is the interaction between Clozapine and Glimepiride-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c at baseline and regularly during clozapine therapy, and increase the antidiabetic regimen if control worsens. Also monitor weight and lipids.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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