Drug interactions
Clozapine + Glycopyrrolate inhaled
Severity: Minor
Clozapine and Glycopyrrolate inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic absorption of inhaled glycopyrrolate is low, but clozapine is strongly anticholinergic and some additive effects are possible. Clinically relevant interaction is expected to be limited at usual inhaled doses.
What this interaction means in plain words
Clozapine and Glycopyrrolate inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive antimuscarinic effects from small systemic exposure to inhaled glycopyrrolate.
What to do
No routine change is needed; watch for constipation, urinary retention and dry mouth, particularly in older patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Glycopyrrolate inhaled?
MediHelp rates the interaction as minor. Clozapine and Glycopyrrolate inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic absorption of inhaled glycopyrrolate is low, but clozapine is strongly anticholinergic and some additive effects are possible. Clinically relevant interaction is expected to be limited at usual inhaled doses.
How serious is the interaction between Clozapine and Glycopyrrolate inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; watch for constipation, urinary retention and dry mouth, particularly in older patients.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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