Drug interactions
Clozapine + Green tea
Severity: Minor
Clozapine and Green tea: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Green tea contains caffeine, which is a CYP1A2 substrate and can compete with clozapine for metabolism. Large intakes may raise clozapine levels, while stopping heavy intake can lower them. Tea tannins may also bind clozapine, but the clinical significance is uncertain.
What this interaction means in plain words
Clozapine and Green tea have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clozapine belongs to Central Nervous System; Green tea belongs to Gastrointestinal Tract.
Why it happens
Caffeine competitively inhibits CYP1A2-mediated clozapine metabolism.
What to do
Keep green tea and caffeine intake consistent. Consider checking clozapine levels if intake changes substantially.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Green tea
- Adenosine + Green tea Moderate
- Benzphetamine + Green tea Moderate
- Bortezomib + Green tea Moderate
- Dextroamphetamine + Green tea Moderate
- Diethylpropion + Green tea Moderate
- Ephedrine + Green tea Moderate
Frequently asked questions
Can I take Clozapine with Green tea?
MediHelp rates the interaction as minor. Clozapine and Green tea have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Green tea contains caffeine, which is a CYP1A2 substrate and can compete with clozapine for metabolism. Large intakes may raise clozapine levels, while stopping heavy intake can lower them. Tea tannins may also bind clozapine, but the clinical significance is uncertain.
How serious is the interaction between Clozapine and Green tea?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep green tea and caffeine intake consistent. Consider checking clozapine levels if intake changes substantially.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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