Drug interactions
Clozapine + Homatropine
Severity: Moderate
Clozapine and Homatropine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Homatropine is an antimuscarinic and clozapine has strong anticholinergic effects. If homatropine is taken systemically (for example in combination cough products), the combination may produce constipation, urinary retention, confusion and tachycardia.
What this interaction means in plain words
Clozapine and Homatropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Homatropine belongs to Genitourinary.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor bowel and bladder function and mental status. Prefer non-anticholinergic alternatives where available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Homatropine
- Amantadine + Homatropine Moderate
- Amitriptyline + Homatropine Moderate
- Atropine + Homatropine Moderate
- Benztropine + Homatropine Moderate
- Bethanechol + Homatropine Moderate
- Chlorpromazine + Homatropine Moderate
Frequently asked questions
Can I take Clozapine with Homatropine?
MediHelp rates the interaction as moderate. Clozapine and Homatropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Homatropine is an antimuscarinic and clozapine has strong anticholinergic effects. If homatropine is taken systemically (for example in combination cough products), the combination may produce constipation, urinary retention, confusion and tachycardia.
How serious is the interaction between Clozapine and Homatropine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel and bladder function and mental status. Prefer non-anticholinergic alternatives where available.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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