Drug interactions
Clozapine + Hydrocortisone
Severity: Minor
Clozapine and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone is a weak CYP3A4 inducer, but clozapine is cleared mainly by CYP1A2, so a relevant change in clozapine levels is unlikely.
What this interaction means in plain words
Clozapine and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clozapine belongs to Central Nervous System; Hydrocortisone belongs to Endocrine.
Why it happens
Theoretical minor CYP3A4 induction; clozapine is mainly CYP1A2 metabolized.
What to do
No adjustment needed; monitor psychiatric response and glucose as routine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Hydrocortisone?
MediHelp rates the interaction as minor. Clozapine and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrocortisone is a weak CYP3A4 inducer, but clozapine is cleared mainly by CYP1A2, so a relevant change in clozapine levels is unlikely.
How serious is the interaction between Clozapine and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment needed; monitor psychiatric response and glucose as routine.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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