Drug interactions
Clozapine + Hyoscyamine spray
Severity: Moderate
Clozapine and Hyoscyamine spray: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine spray is absorbed through the oral mucosa and has systemic antimuscarinic effects, adding to clozapine's anticholinergic burden. This may cause constipation or ileus, urinary retention, confusion and tachycardia.
What this interaction means in plain words
Clozapine and Hyoscyamine spray can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor bowel function, urinary symptoms and mental status, and use the lowest effective hyoscyamine dose. Discontinue it if signs of obstruction or delirium appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Hyoscyamine spray?
MediHelp rates the interaction as moderate. Clozapine and Hyoscyamine spray can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hyoscyamine spray is absorbed through the oral mucosa and has systemic antimuscarinic effects, adding to clozapine's anticholinergic burden. This may cause constipation or ileus, urinary retention, confusion and tachycardia.
How serious is the interaction between Clozapine and Hyoscyamine spray?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function, urinary symptoms and mental status, and use the lowest effective hyoscyamine dose. Discontinue it if signs of obstruction or delirium appear.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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