Drug interactions
Clozapine + Indinavir
Severity: Moderate
Clozapine and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4, which contributes to clozapine metabolism, and may raise clozapine concentrations. Higher exposure may cause sedation, hypotension, seizures and QT effects.
What this interaction means in plain words
Clozapine and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by indinavir reduces clozapine clearance.
What to do
Monitor for clozapine adverse effects and consider checking clozapine levels. Reduce the clozapine dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Indinavir?
MediHelp rates the interaction as moderate. Clozapine and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir inhibits CYP3A4, which contributes to clozapine metabolism, and may raise clozapine concentrations. Higher exposure may cause sedation, hypotension, seizures and QT effects.
How serious is the interaction between Clozapine and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for clozapine adverse effects and consider checking clozapine levels. Reduce the clozapine dose if toxicity develops.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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