Drug interactions
Clozapine + Insulin nph
Severity: Moderate
Clozapine and Insulin nph: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine can induce insulin resistance and hyperglycemia, reducing the glucose-lowering effect of NPH insulin. Diabetes control may deteriorate and insulin needs may increase.
What this interaction means in plain words
Clozapine and Insulin nph can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism through clozapine-induced insulin resistance and metabolic effects.
What to do
Monitor glucose and HbA1c regularly and adjust the insulin dose when clozapine is started, changed or discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Insulin nph?
MediHelp rates the interaction as moderate. Clozapine and Insulin nph can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine can induce insulin resistance and hyperglycemia, reducing the glucose-lowering effect of NPH insulin. Diabetes control may deteriorate and insulin needs may increase.
How serious is the interaction between Clozapine and Insulin nph?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c regularly and adjust the insulin dose when clozapine is started, changed or discontinued.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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