Drug interactions
Clozapine + Isradipine
Severity: Minor
Clozapine and Isradipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isradipine is not an established QT-prolonging drug, so a meaningful QT interaction is doubtful. However, both drugs can lower blood pressure, and combined use may cause additive hypotension or reflex tachycardia.
What this interaction means in plain words
Clozapine and Isradipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive hypotensive effects from clozapine alpha-1 blockade and isradipine vasodilation.
What to do
Monitor blood pressure and orthostatic symptoms when starting or titrating either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Isradipine?
MediHelp rates the interaction as minor. Clozapine and Isradipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isradipine is not an established QT-prolonging drug, so a meaningful QT interaction is doubtful. However, both drugs can lower blood pressure, and combined use may cause additive hypotension or reflex tachycardia.
How serious is the interaction between Clozapine and Isradipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or titrating either drug.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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