Drug interactions
Clozapine + Lisuride
Severity: Moderate
Clozapine and Lisuride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lisuride is a dopamine agonist, whereas clozapine blocks dopamine receptors, so each may counteract the other's effect. Dopamine agonists can also worsen psychosis, which is the condition clozapine treats.
What this interaction means in plain words
Clozapine and Lisuride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism at dopamine receptors.
What to do
Monitor for worsening psychosis or reduced control of parkinsonian symptoms. Clozapine is often preferred in Parkinson's psychosis, so adjust the dopamine agonist dose to the lowest effective level.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Lisuride?
MediHelp rates the interaction as moderate. Clozapine and Lisuride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lisuride is a dopamine agonist, whereas clozapine blocks dopamine receptors, so each may counteract the other's effect. Dopamine agonists can also worsen psychosis, which is the condition clozapine treats.
How serious is the interaction between Clozapine and Lisuride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for worsening psychosis or reduced control of parkinsonian symptoms. Clozapine is often preferred in Parkinson's psychosis, so adjust the dopamine agonist dose to the lowest effective level.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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