Drug interactions
Clozapine + Loprazolam
Severity: Major
Clozapine and Loprazolam: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine combined with a benzodiazepine increases sedation. Clozapine labeling warns of orthostatic hypotension, bradycardia, syncope and rare cardiorespiratory collapse, especially with benzodiazepines.
What this interaction means in plain words
Clozapine and Loprazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depression, with additive hypotensive and respiratory depressant effects.
What to do
Use the lowest benzodiazepine dose and titrate clozapine slowly, monitoring sedation, blood pressure and respiratory status. Avoid combined initiation in frail or respiratory-compromised patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Loprazolam?
MediHelp rates the interaction as major. Clozapine and Loprazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clozapine combined with a benzodiazepine increases sedation. Clozapine labeling warns of orthostatic hypotension, bradycardia, syncope and rare cardiorespiratory collapse, especially with benzodiazepines.
How serious is the interaction between Clozapine and Loprazolam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest benzodiazepine dose and titrate clozapine slowly, monitoring sedation, blood pressure and respiratory status. Avoid combined initiation in frail or respiratory-compromised patients.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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