Drug interactions
Clozapine + Lormetazepam
Severity: Major
Clozapine and Lormetazepam: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine combined with a benzodiazepine hypnotic increases sedation and the risk of orthostatic hypotension. Rare cases of respiratory depression or collapse have been described with this type of combination.
What this interaction means in plain words
Clozapine and Lormetazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depression, with additive hypotensive and respiratory depressant effects.
What to do
Use the lowest benzodiazepine dose and titrate slowly, monitoring sedation, blood pressure and respiration. Avoid alcohol and other sedatives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Lormetazepam?
MediHelp rates the interaction as major. Clozapine and Lormetazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clozapine combined with a benzodiazepine hypnotic increases sedation and the risk of orthostatic hypotension. Rare cases of respiratory depression or collapse have been described with this type of combination.
How serious is the interaction between Clozapine and Lormetazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest benzodiazepine dose and titrate slowly, monitoring sedation, blood pressure and respiration. Avoid alcohol and other sedatives.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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