Drug interactions
Clozapine + Loxapine inhaled
Severity: Moderate
Clozapine and Loxapine inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antipsychotics, so combined use adds dopamine blockade and sedation, raising the risk of extrapyramidal symptoms, neuroleptic malignant syndrome and orthostasis. Inhaled loxapine may also cause bronchospasm, and clozapine adds respiratory and circulatory risk.
What this interaction means in plain words
Clozapine and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive dopamine D2 antagonism and CNS depression.
What to do
Observe the patient after inhaled loxapine for sedation, hypotension and bronchospasm. Monitor for rigidity, fever and autonomic instability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Loxapine inhaled?
MediHelp rates the interaction as moderate. Clozapine and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are antipsychotics, so combined use adds dopamine blockade and sedation, raising the risk of extrapyramidal symptoms, neuroleptic malignant syndrome and orthostasis. Inhaled loxapine may also cause bronchospasm, and clozapine adds respiratory and circulatory risk.
How serious is the interaction between Clozapine and Loxapine inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Observe the patient after inhaled loxapine for sedation, hypotension and bronchospasm. Monitor for rigidity, fever and autonomic instability.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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