Drug interactions
Clozapine + Methylergonovine
Severity: Moderate
Clozapine and Methylergonovine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylergonovine is an ergot derivative with serotonergic receptor activity and is metabolized by CYP3A4. Clozapine has serotonergic effects, and a possible additive effect on serotonin toxicity has been proposed, though evidence is limited. Ergot use is typically brief in postpartum settings.
What this interaction means in plain words
Clozapine and Methylergonovine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic and vasoconstrictive effects; no firmly established mechanism.
What to do
Monitor for agitation, tremor, hyperthermia and vasospasm during use. Keep the course of methylergonovine as short as possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Methylergonovine?
MediHelp rates the interaction as moderate. Clozapine and Methylergonovine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methylergonovine is an ergot derivative with serotonergic receptor activity and is metabolized by CYP3A4. Clozapine has serotonergic effects, and a possible additive effect on serotonin toxicity has been proposed, though evidence is limited. Ergot use is typically brief in postpartum settings.
How serious is the interaction between Clozapine and Methylergonovine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia and vasospasm during use. Keep the course of methylergonovine as short as possible.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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