Drug interactions
Clozapine + Phendimetrazine
Severity: Moderate
Clozapine and Phendimetrazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phendimetrazine is a sympathomimetic anorectic whose stimulant effects may partly offset clozapine sedation, but can also add to tachycardia and blood pressure changes. Clozapine already causes tachycardia and cardiometabolic effects, and stimulants may worsen psychosis.
What this interaction means in plain words
Clozapine and Phendimetrazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing pharmacodynamic effects of sympathomimetic stimulation and clozapine's sedative, dopamine and adrenergic blocking actions.
What to do
Monitor heart rate, blood pressure and psychiatric symptoms, and prefer a non-stimulant weight management approach.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Phendimetrazine?
MediHelp rates the interaction as moderate. Clozapine and Phendimetrazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phendimetrazine is a sympathomimetic anorectic whose stimulant effects may partly offset clozapine sedation, but can also add to tachycardia and blood pressure changes. Clozapine already causes tachycardia and cardiometabolic effects, and stimulants may worsen psychosis.
How serious is the interaction between Clozapine and Phendimetrazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and psychiatric symptoms, and prefer a non-stimulant weight management approach.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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