Drug interactions
Clozapine + Scullcap
Severity: Moderate
Clozapine and Scullcap: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Scullcap is a herbal product with traditional sedative properties, and it may add to the pronounced sedation caused by clozapine. Daytime drowsiness and psychomotor impairment could be increased. Clinical data are scarce.
What this interaction means in plain words
Clozapine and Scullcap can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects, probably via GABAergic activity of the herb; the interaction is largely theoretical.
What to do
Advise patients to avoid scullcap, or monitor for excessive sedation and impaired alertness, especially when driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Scullcap?
MediHelp rates the interaction as moderate. Clozapine and Scullcap can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Scullcap is a herbal product with traditional sedative properties, and it may add to the pronounced sedation caused by clozapine. Daytime drowsiness and psychomotor impairment could be increased. Clinical data are scarce.
How serious is the interaction between Clozapine and Scullcap?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid scullcap, or monitor for excessive sedation and impaired alertness, especially when driving.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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