Drug interactions
Clozapine + Shepherd's purse
Severity: Minor
Clozapine and Shepherd's purse: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Shepherd's purse is a herbal product with reported mild sedative activity, so it might add to clozapine-related sedation. The supporting evidence is minimal.
What this interaction means in plain words
Clozapine and Shepherd's purse have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depression; the mechanism is not well established.
What to do
Ask patients about herbal use and monitor for increased drowsiness if the product is taken.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Shepherd's purse?
MediHelp rates the interaction as minor. Clozapine and Shepherd's purse have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Shepherd's purse is a herbal product with reported mild sedative activity, so it might add to clozapine-related sedation. The supporting evidence is minimal.
How serious is the interaction between Clozapine and Shepherd's purse?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about herbal use and monitor for increased drowsiness if the product is taken.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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