Drug interactions
clozapine + smoking cessation (fluvoxamine)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Fluvoxamine + smoking stop → dramatic ↑ clozapine.
Mechanism of action
CYP1A2 inhibition + loss of induction.
Clinical management
Avoid/monitor; adjust dose based on levels.
Drug reference
References
Frequently asked questions
Can I take clozapine with smoking cessation (fluvoxamine)?
The interaction is rated: Major. Fluvoxamine + smoking stop → dramatic ↑ clozapine.
How serious is the interaction between clozapine and smoking cessation (fluvoxamine)?
The interaction is rated: Major. Evidence level: High.
How is the interaction between clozapine and smoking cessation (fluvoxamine) managed?
Avoid/monitor; adjust dose based on levels.
Why do clozapine and smoking cessation (fluvoxamine) interact?
CYP1A2 inhibition + loss of induction.
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