Drug interactions
clozapine + smoking (nicotine replacement)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Level shifts with smoking changes (CYP1A2 induction).
Mechanism of action
PAH-induced CYP1A2 induction.
Clinical management
Monitor levels when smoking status changes.
Drug reference
References
Frequently asked questions
Can I take clozapine with smoking (nicotine replacement)?
The interaction is rated: Major. Level shifts with smoking changes (CYP1A2 induction).
How serious is the interaction between clozapine and smoking (nicotine replacement)?
The interaction is rated: Major. Evidence level: Moderate.
How is the interaction between clozapine and smoking (nicotine replacement) managed?
Monitor levels when smoking status changes.
Why do clozapine and smoking (nicotine replacement) interact?
PAH-induced CYP1A2 induction.
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