Drug interactions
Clozapine + Somatropin
Severity: Minor
Clozapine and Somatropin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone may increase the activity of some cytochrome P450 enzymes and could lower clozapine concentrations. The data are limited and a clinically meaningful effect is uncertain.
What this interaction means in plain words
Clozapine and Somatropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clozapine belongs to Central Nervous System; Somatropin belongs to Endocrine.
Why it happens
Possible induction of CYP1A2-mediated metabolism by somatropin, which is not firmly established.
What to do
Watch for loss of psychiatric response after somatropin is started and consider checking clozapine levels if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Frequently asked questions
Can I take Clozapine with Somatropin?
MediHelp rates the interaction as minor. Clozapine and Somatropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone may increase the activity of some cytochrome P450 enzymes and could lower clozapine concentrations. The data are limited and a clinically meaningful effect is uncertain.
How serious is the interaction between Clozapine and Somatropin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for loss of psychiatric response after somatropin is started and consider checking clozapine levels if control worsens.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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