Drug interactions
Clozapine + Sumatriptan intranasal
Severity: Moderate
Clozapine and Sumatriptan intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptans and antipsychotics have both been linked to serotonin toxicity in rare reports, and clozapine has some serotonergic activity. The risk is low but the syndrome can be serious.
What this interaction means in plain words
Clozapine and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic effects (5-HT1B/1D agonism with clozapine 5-HT2A antagonism); the mechanism is theoretical.
What to do
Counsel patients to report agitation, tremor, fever, sweating or rigidity, and monitor for serotonin toxicity or neuroleptic malignant syndrome after the triptan dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Sumatriptan intranasal?
MediHelp rates the interaction as moderate. Clozapine and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triptans and antipsychotics have both been linked to serotonin toxicity in rare reports, and clozapine has some serotonergic activity. The risk is low but the syndrome can be serious.
How serious is the interaction between Clozapine and Sumatriptan intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report agitation, tremor, fever, sweating or rigidity, and monitor for serotonin toxicity or neuroleptic malignant syndrome after the triptan dose.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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