Drug interactions
Clozapine + Triprolidine
Severity: Moderate
Clozapine and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine is strongly sedating and anticholinergic. Adding triprolidine intensifies drowsiness and anticholinergic effects, with a risk of constipation that can progress to severe ileus, as well as urinary retention and confusion.
What this interaction means in plain words
Clozapine and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Triprolidine belongs to Respiratory.
Why it happens
Additive CNS depression and additive antimuscarinic and antihistaminic effects.
What to do
Monitor for oversedation and constipation, and review bowel function regularly. Avoid sedating antihistamines in patients with a history of constipation or ileus.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Triprolidine?
MediHelp rates the interaction as moderate. Clozapine and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine is strongly sedating and anticholinergic. Adding triprolidine intensifies drowsiness and anticholinergic effects, with a risk of constipation that can progress to severe ileus, as well as urinary retention and confusion.
How serious is the interaction between Clozapine and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and constipation, and review bowel function regularly. Avoid sedating antihistamines in patients with a history of constipation or ileus.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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