Drug interactions
Clozapine + Yohimbine
Severity: Moderate
Clozapine and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist that increases noradrenergic activity and may counter clozapine sedation and hypotension. It can also cause anxiety, agitation and tachycardia, which could worsen psychiatric symptoms. The combined effect is unpredictable.
What this interaction means in plain words
Clozapine and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing pharmacodynamic actions: alpha-2 blockade versus clozapine's alpha-adrenergic blockade and sedation.
What to do
Avoid yohimbine in patients with psychotic disorders where possible, and monitor blood pressure, heart rate and mental state if used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Yohimbine?
MediHelp rates the interaction as moderate. Clozapine and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine is an alpha-2 antagonist that increases noradrenergic activity and may counter clozapine sedation and hypotension. It can also cause anxiety, agitation and tachycardia, which could worsen psychiatric symptoms. The combined effect is unpredictable.
How serious is the interaction between Clozapine and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid yohimbine in patients with psychotic disorders where possible, and monitor blood pressure, heart rate and mental state if used.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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