Drug interactions
Cobimetinib + Isoniazid
Severity: Moderate
Cobimetinib and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid is a weak-to-moderate CYP3A4 inhibitor and may raise cobimetinib exposure, increasing the risk of toxicity such as rash, diarrhea, hemorrhage, and liver injury. The large increase seen with strong inhibitors is not expected with isoniazid.
What this interaction means in plain words
Cobimetinib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cobimetinib belongs to Oncology; Isoniazid belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated metabolism of cobimetinib.
What to do
Monitor for cobimetinib adverse effects and liver enzymes. Consider reducing the cobimetinib dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Cobimetinib
- Cobimetinib + Efavirenz Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Amobarbital + Cobimetinib Major
- Apalutamide + Cobimetinib Major
- Aprepitant + Cobimetinib Major
- Bosentan + Cobimetinib Major
Frequently asked questions
Can I take Cobimetinib with Isoniazid?
MediHelp rates the interaction as moderate. Cobimetinib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid is a weak-to-moderate CYP3A4 inhibitor and may raise cobimetinib exposure, increasing the risk of toxicity such as rash, diarrhea, hemorrhage, and liver injury. The large increase seen with strong inhibitors is not expected with isoniazid.
How serious is the interaction between Cobimetinib and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cobimetinib adverse effects and liver enzymes. Consider reducing the cobimetinib dose if toxicity occurs.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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