Drug interactions
Cobimetinib + Posaconazole
Severity: Contraindicated
Cobimetinib and Posaconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole markedly raises cobimetinib exposure, increasing risks of hemorrhage, rhabdomyolysis, retinopathy, diarrhea and skin toxicity.
What this interaction means in plain words
Cobimetinib and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cobimetinib belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition reduces cobimetinib clearance.
What to do
Avoid; use an antifungal or other therapy without strong CYP3A4 inhibition. If unavoidable, follow labeling for substantial cobimetinib dose reduction and monitor for toxicity.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
- Dronedarone + Posaconazole Contraindicated
Other interactions of Cobimetinib
- Cobimetinib + Efavirenz Contraindicated
- Amobarbital + Cobimetinib Major
- Apalutamide + Cobimetinib Major
- Aprepitant + Cobimetinib Major
- Bosentan + Cobimetinib Major
- Carbamazepine + Cobimetinib Major
Frequently asked questions
Can I take Cobimetinib with Posaconazole?
MediHelp rates the interaction as contraindicated. Cobimetinib and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Posaconazole markedly raises cobimetinib exposure, increasing risks of hemorrhage, rhabdomyolysis, retinopathy, diarrhea and skin toxicity.
How serious is the interaction between Cobimetinib and Posaconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid; use an antifungal or other therapy without strong CYP3A4 inhibition. If unavoidable, follow labeling for substantial cobimetinib dose reduction and monitor for toxicity.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Conivaptan. The full list is on the Posaconazole page.
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